I worked at the Mayo Clinic in Jacksonville Florida from 1997 to 2003 looking into the effects of mutations in the MAPT gene and how they might influence microtubule function, protein aggregation and how they influence alternative splicing of the MAPT mRNA to alter the ratio of protein isoforms of the Tau protein in neurons of the CNS. My doctoral thesis was based on this work.
From 2003 - 2013 I worked as a Research Fellow, then a Staff Scientist at the Banner Sun Health Research Institute, investigating the underlying causes of Alzheimer's disease and other neurodegenerative diseases such as Parkinson's disease.
I have been an Adjunct Faculty/OYO/OSO member at EMCC from 2014 - present.
Selected from 33 publications.
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, et al
Nature. 1998 Jun 18;393(6686):702-5. PMID: 9641683.
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
Grover A, et al
J Biol Chem. 1999 May 21;274(21):15134-43. PMID: 10329720.
Effects on splicing and protein function of three mutations in codon N296 of tau in vitro.
Grover A, DeTure M, Yen SH, Hutton M.
Neurosci Lett. 2002 Apr 19;323(1):33-6. PMID: 11911984
A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy.
Grover A, et al
Exp Neurol. 2003 Nov;184(1):131-40. PMID: 14637086.
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation.
Mastroeni D, Grover A, et al
Neurobiol Aging. 2010 Dec;31(12):2025-37. PMID: 19117641; PMCID: PMC2962691.
Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, et al
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4441-6. PMID: 18332434; PMCID: PMC2393743.
Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease.
Leonard BW, Mastroeni D, Grover A, et al
J Comp Neurol. 2009 Jul 20;515(3):269-94. PMID: 19425077; PMCID: PMC2757160.
2018/19 National Institute for Staff and Organizational Development (NISOD) Excellence Award.